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Introduction of group leader
Office phone: +82-31-8018-8194
Office location: R4.37
Institut Pasteur Korea’s Antibacterial Resistance Research Laboratory focuses on the discovery of new antibacterial agents that can be used to fight against ‘superbugs’. ‘Superbugs’ is a term to describe bacteria that cannot be killed by most of current available antibiotics. Infections caused by these antibiotic resistant ‘superbugs’ are, therefore, often life-threatening and extremely difficult to treat. Rapid emergence and spread of ‘superbugs’ are an increasingly serious threat to public health in Korea as well as globally.
In order to discover novel antibacterial agents active against ‘superbugs’, the strategies of our research are 1) to extend knowledge of bacterial physiology and resistant mechanisms, 2) to apply the knowledge for developing new screening systems, and 3) to identify new entities through developed systems.
Research is conducted on the following major pathogenic bacteria Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumonias, with activity focuses on:
• Discovery of new antibacterial agents through development of innovative screening systems and identification of novel targets
• Investigation of resistance development mechanism in Gram positive bacteria
• Surveillance of antibiotic resistance in community
The research conducted will provide the basis for future studies that address antibiotic resistance and the discovery of new entities aims to fill the antibiotic development pipeline.
The ThiL enzyme is a valid antibacterial target essential for both thiamine biosynthesis and salvage pathways in Pseudomonas aeruginosa
Hyung Jun Kim, Hyunjung Lee, Yunmi Lee, Inhee Choi, Yoonae Ko, Sangchul Lee, Soojin Jang
J Biol Chem. 2020 Jul 17;295(29):10081-10091
Optimization of a resazurin-based microplate assay for large-scale compound screenings against Klebsiella pneumoniae
Hyung Jun Kim, Soojin Jang
3 Biotech. 2018 Jan;8(1):3
Detection of bacterial sulfatase activity through liquid- and solid-phase colony-based assays.
Hey Young Yoon, Hyung Jun Kim, Soojin Jang, Jong-In Hong
AMB Express. 2017 Dec;7(1):150
Draft genome sequence of multidrug-resistant Staphylococcus haemolyticus IPK_TSA25 harbouring a Staphylococcus aureus plasmid, pS0385-1.
Hyung Jun Kim, Soojin Jang
J Glob Antimicrob Resist. 2017 Dec;11:8-9
Identification of Antipneumococcal Molecules Effective Against Different Streptococcus pneumoniae Serotypes Using a Resazurin-Based High-Throughput Screen.
Hyung Jun Kim, Namyoul Kim, David Shum, Srigouri Huddar, Chul Min Park, Soojin Jang
Assay Drug Dev Technol. 2017 Jul;15(5):198-209