Institut Pasteur Korea - Host-Parasite Research Lab.



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Host-Parasite Research Lab

Introduction of group leader

Joo Hwan No, Ph.D.
Doctorate: University of Illinois at Urbana-Champaign, USA (2011)
Post-Doctorate: Institut Pasteur Korea (2011-2013)
Head, Leishmania Research Laboratory, Institut Pasteur Korea (2013-2021)
Head, Host-Parasite Research Laboratory, Institut Pasteur Korea (2021~present)

Office phone: +82-31-8018-8210
Office location: R4.07

Research Interests

The Host-Parasite Research Lab focuses on discovery of novel inhibitors and drug targets against Leishmania infections. The research activities are focused on two key areas: 1) discovery of novel lead compounds in collaboration with screening and chemistry platforms offered at IPK, and 2) understanding the fundamental biology of Leishmania with a special emphasis on the host – Leishmania interaction. At the interface of these two approaches, we ultimately aim to understand the underlying mechanism of parasite pathogenesis as well as to deliver novel therapeutic interventions for Leishmania infections.

Based on our expertise of molecular parasitology, biochemistry and biophysics, we will approach the target system from the parasite or organelle level, as well as the atomic or molecular level.

Our present activity focuses on:
• Identifying hit compounds using intracellular Leishmania high contents/high throughput screening methods
• Hit to lead optimization of identified anti-leishmanial compounds
• Mode of action studies on generated lead compounds
• In-depth understanding of host-Leishmania interactions through cell-based screening and molecular parasitology approaches



 

Recent Publications

Pyrrolidine-based 3-deoxysphingosylphosphorylcholine analogs as possible candidates against neglected tropical diseases (NTDs): identification of hit compounds towards development of potential treatment of Leishmania donovani.
Ahmed H. E. Hassan, Trong-Nhat Phan, Seolmin Yoon, Cheol Jung Lee, Hye Rim Jeon, Seung-Hwan Kim, Joo Hwan No, Yong Sup Lee
J Enzyme Inhib Med Chem. 2021 Dec;36(1):1922-1930

Discovery of Leishmania donovani topoisomerase IB selective inhibitors by targeting protein-protein interactions between the large and small subunits. 
Hyeryon Lee, Kyung-Hwa Baek, Trong-Nhat Phan, I Seul Park, Sangchul Lee, Jiho Kim, Joo Hwan No
Biochem Biophys Res Commun. 2021 Sep 10;569:193-198

Infectivity and Drug Susceptibility Profiling of Different Leishmania-Host Cell Combinations
Kyung-Hwa Baek, Laura Piel, Thibault Rosazza, Eric Prina, Gerald F. Späth, and Joo Hwan No
Pathogens. 2020 May; 9(5): 393

In Vitro and in Vivo Activity of mTOR Kinase and PI3K Inhibitors Against Leishmania donovani and Trypanosoma brucei
Trong-Nhat Phan, Kyung-Hwa Baek, Nakyung Lee, Soo Young Byun, David Shum, and Joo Hwan No
Molecules. 2020 Apr; 25(8): 1980

Evaluation of Parameters Impacting Drug Susceptibility in Intracellular Trypanosoma cruzi Assay Protocols. (Front Cover)
Yang G, Lee N, Ioset JR, No JH
SLAS Discov. 2017 Feb;22(2):125-134