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Introduction of group leader
Office phone: +82-31-8018-8350
Office location: R4.31
The research objectives of Viral Immunology Laboratory is to discover preventive and therapeutic strategies to pathogenic infections by understanding immune responses and immunopathology triggered by them. Particularly, we are focusing on innate and adaptive immunity to viruses such as influenza viruses that have been steadily intimidating human race for centuries, and newly emerging corona viruses including SARS-CoV-2 (COVID-19) which resulted in a global pandemic as well as MERS-CoV.
In addition, our lab is also interested in revealing underlying mechanisms of immune-suppression and immune exhaustion induced by chronic viral infections. Since the immune exhaustion is also frequently elicited by cancers as an immune evasion method, we would like to ultimately find immunological intervention strategies to treat chronic viral infections and cancers.
Our research interests can be summarized as follows:
- Study on in vivo immune responses and immunopathology triggered by influenza and corona viruses
- Investigation of underlying mechanisms of immuno-suppression and immune exhaustion induced by
chronic viral infections and cancers
- Identification of novel immune-regulatory molecules using an innovative cell-based high
throughput screening system
Role of Damage-Associated Molecular Pattern/Cell Death Pathways in Vaccine-Induced Immunity.
Sun Min Lee, Paul Kim, Jinsuh You, Eui Ho Kim
Viruses. 2021 Nov 23;13(12), 2340
Immune responses and reactogenicity after ChAdOx1 in individuals with past SARSCoV-2 infection and those without.
So Yun Lim, Ji Yeun Kim, Jin Ah Lee, Ji-Soo Kwon, Ji Young Park, Hye Hee Cha, Mi Hyun Suh, Hyun Jung Lee, Hyeonju Kim, Seungtaek Kim, Seongman Bae, Jiwon Jung, Eui Ho Kim, Youngmee Jee, Sung-Han Kim
Journal of Infection. 2021 Jul 28;S0163-4453(21)00375-3
The amphibian host defense peptide Yodha is virucidal for Zika and Dengue viruses.
Song Hee Lee, Eui Ho Kim, Justin T O'neal, Gordon Dale, David J Holthausen, James R Bowen, Kendra M Quicke, Ioanna Skountzou, Shyla Gopal, Sanil George, Jens Wrammert, Mehul S Suthar, Joshy Jacob
Scientific Reports. 2021 Jan 12;11(1):602
Squalene-based adjuvants stimulate CD8 T cell, but not antibody responses, through a RIPK3-dependent pathway.
Eui Ho Kim, Matthew C Woodruff, Lilit Grigoryan, Barbara Maier, Song Hee Lee, Pratyusha Mandal, Mario Cortese, Muktha S Natrajan, Rajesh Ravindran, Huailiang Ma, Miriam Merad, Alexander D Gitlin, Edward S Mocarski, Joshy Jacob, Bali Pulendran
eLife. 2020 Jun 9;9:e52687
B cell competition for restricted T cell help suppresses rare-epitope response.
Matthew Charles Woodruff, Eui Ho Kim, Wei Luo, Bali Pulendran
Cell Reports. 2018 Oct 9;25:321-327