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Introduction of group leader
Office phone: +82-31-8018-8230
Office location: R4.03
Global climate changes and frequent international travels across continents have facilitated transmissions of novel infectious viral agents. Such incidents have been documented in the recent MERS-CoV and Zika virus outbreak in Korea and South America. We are particularly interested in these new emerging viruses and try to pursue further understanding of their virology and development of therapeutic agents such as therapeutic antibodies and small molecule inhibitors.
We are also interested in antiviral resistance, particularly novel resistant mutations observed in chronic hepatitis B and C patients despite treatment with the most potent direct-acting antivirals (DAAs) such as tenofovir and sofosbuvir. Identification and understanding of such mutations is very important in that we can identify patients who will respond better to the DAA treatment and provide the future guideline for selecting the retreatment options.
Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs
Sangeun Jeon, Meehyun Ko, Jihye Lee, Inhee Choi, Soo Young Byun, Soonju Park, David Shum, Seungtaek Kim
Antimicrob Agents Chemother. 2020 Jun 23;64(7):e00819-20
Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells
Meehyun Ko, Sangeun Jeon, Wang-Shick Ryu, Seungtaek Kim
J Med Virol. 2021 Mar;93(3):1403-1408
Generation of a Nebulizable CDR-Modified MERS-CoV Neutralizing Human Antibody
Sang Il Kim, Sujeong Kim, Jinhee Kim, So Young Chang, Jung Min Shim, Jongwha Jin, Chungsu Lim, Songyi Baek, Ji-Young Min, Wan Beom Park, Myoung-Don Oh, Seungtaek Kim, Junho Chung
Int J Mol Sci. 2019 Oct 12;20(20):5073
Evolution and persistence of resistance-associated substitutions of hepatitis C virus after direct-acting antiviral treatment failures
Yechan Jeong, Bora Jin, Hye Won Lee, Hye Jung Park, Jun Yong Park, Do Young Kim, Kwang-Hyub Han, Sang Hoon Ahn, Seungtaek Kim
J Viral Hepat. 2018 Nov;25(11):1251-1259
Effect of S267F variant of NTCP on the patients with chronic hepatitis B.
Hye Won Lee, Hye Jung Park, Bora Jin, Mehrangiz Dezhbord, Do Young Kim, Kwang-Hyub Han, Wang-Shick Ryu, Seungtaek Kim*, Sang Hoon Ahn*
Sci Rep. 2017 Dec 15;7(1):17634