Institut Pasteur Korea - Zoonotic Virus Lab.

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Zoonotic Virus Lab

Introduction of group leader

Seungtaek Kim, Ph.D.
Doctorate: Iowa State University (2004)
Post-Doctorate: HHMI/University of Wisconsin-Madison (2004-2006) (PI: Dr. Paul Ahlquist)
Post-Doctorate: UTMB/University of North Carolina at Chapel Hill (2007-2012) (PI: Dr. Stanley M. Lemon)
Research Assistant Professor, Yonsei University College of Medicine (2012-2017)
Instructor, Department of Biochemistry, Yonsei University (2017-2018)
Head, Zoonotic Virus Lab, Institut Pasteur Korea (2017-Present)

Office phone: +82-31-8018-8230
Office location: R4.03

Research Interests

Global climate changes and frequent international travels across continents have facilitated transmissions of novel infectious viral agents. Such incidents have been documented in the recent MERS-CoV and Zika virus outbreak in Korea and South America. We are particularly interested in these new emerging viruses and try to pursue further understanding of their virology and development of therapeutic agents such as therapeutic antibodies and small molecule inhibitors.
We are also interested in antiviral resistance, particularly novel resistant mutations observed in chronic hepatitis B and C patients despite treatment with the most potent direct-acting antivirals (DAAs) such as tenofovir and sofosbuvir. Identification and understanding of such mutations is very important in that we can identify patients who will respond better to the DAA treatment and provide the future guideline for selecting the retreatment options.

Recent Publications

Drugs repurposed for COVID-19 by virtual screening of 6,218 drugs and cell-based assay
Woo Dae Jang, Sangeun Jeon, Seungtaek Kim, Sang Yup Lee
Proc Natl Acad Sci USA. 2021 Jul 27;118(30):e2024302118

TMPRSS2 and RNA-Dependent RNA Polymerase Are Effective Targets of Therapeutic Intervention for Treatment of COVID-19 Caused by SARS-CoV-2 Variants (B.1.1.7 and B.1.351)
Jihye Lee, JinAh Lee, Hyeon Ju Kim, Meehyun Ko, Youngmee Jee, Seungtaek Kim
Microbiol Spectr. 2021 Sep 3;9(1):e0047221

Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells
Meehyun Ko, Sangeun Jeon, Wang-Shick Ryu, Seungtaek Kim
J Med Virol. 2021 Mar;93(3):1403-1408

Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs
Sangeun Jeon, Meehyun Ko, Jihye Lee, Inhee Choi, Soo Young Byun, Soonju Park, David Shum, Seungtaek Kim
Antimicrob Agents Chemother. 2020 Jun 23;64(7):e00819-20

Generation of a Nebulizable CDR-Modified MERS-CoV Neutralizing Human Antibody
Sang Il Kim, Sujeong Kim, Jinhee Kim, So Young Chang, Jung Min Shim, Jongwha Jin, Chungsu Lim, Songyi Baek, Ji-Young Min, Wan Beom Park, Myoung-Don Oh, Seungtaek Kim, Junho Chung
Int J Mol Sci. 2019 Oct 12;20(20):5073