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Introduction of group leader
Office phone: +82-31-8018-8230
Office location: R4.03
Global climate changes and frequent international travels across continents have facilitated transmissions of novel infectious viral agents. Such incidents have been documented in the recent MERS-CoV and Zika virus outbreak in Korea and South America. We are particularly interested in these new emerging viruses and try to pursue further understanding of their virology and development of therapeutic agents such as therapeutic antibodies and small molecule inhibitors.
We are also interested in antiviral resistance, particularly novel resistant mutations observed in chronic hepatitis B and C patients despite treatment with the most potent direct-acting antivirals (DAAs) such as tenofovir and sofosbuvir. Identification and understanding of such mutations is very important in that we can identify patients who will respond better to the DAA treatment and provide the future guideline for selecting the retreatment options.
Evolution and persistence of resistance-associated substitutions of hepatitis C virus after direct-acting antiviral treatment failures.
Jeong Y, Jin B, Lee HW, Park HJ, Park JY, Kim DY, Han KH, Ahn SH, Kim S
J Viral Hepat. 2018 May 16. doi: 10.1111/jvh.12932. [Epub ahead of print]
Effect of S267F variant of NTCP on the patients with chronic hepatitis B.
Lee HW, Park HJ, Jin B, Dezhbord M, Kim DY, Han KH, Ryu WS, Kim S*, Ahn SH*
Sci Rep. 2017 Dec 15;7(1):17634
Regulation of the hepatitis C virus RNA replicase by endogenous lipid peroxidation.
Yamane D, McGivern DR, Wauthier E, Yi M, Madden VJ, Welsch C, Antes I, Wen Y, Chugh PE, McGee CE, Widman DG, Misumi I, Bandyopadhyay S, Kim S, Shimakami T, Oikawa T, Whitmire JK, Heise MT, Dittmer DP, Kao CC, Pitson SM, Merrill AH Jr, Reid LM, Lemon SM
Nat Med. 2014 Aug;20(8):927-35
Loss of immune escape mutations during persistent HCV infection in pregnancy enhances replication of vertically transmitted viruses.
Honegger JR, Kim S, Price AA, Kohout JA, McKnight KL, Prasad MR, Lemon SM, Grakoui A, Walker CM
Nat Med. 2013 Nov;19(11):1529-33
Contrasting roles of mitogen-activated protein kinases in cellular entry and replication of hepatitis C virus: MKNK1 facilitates cell entry.
Kim S, Ishida H, Yamane D, Yi M, Swinney DC, Foung S, Lemon SM
J Virol. 2013 Apr;87(8):4214-24