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Assays & Technologies

Tuberculosis Research Laboratory

QIM assay [Code No: IPK0101]

This ex vivo assay in Mycobacterium tuberculosis-infected macrophages is used to monitor TB infection inside the cell by confocal fluorescent microscopy. This assay is the first cellular model to visualize the infection process of Mycobacterium tuberculosis inside human macrophages.

QUM assay [Code No: IPK0102]

This is a bacteriostatic assay using the M. tuberculosis-gfp strain. This assay can be measured by Victor 3.

MDR/XDR assay [Code No: IPK0103]

This is a QIM/QUM assay that uses MDR and XDR clinical isolates.

MBC assay [Code No: IPK0104]

This agar plate-based assay can be used to measure the bactericidal properties of compounds.

ATP depletion assay [Code No: IPK0105]

This assay measures ATP depletion of M. tuberculosis in aerobic and anaerobic conditions.

Thin Layer Chromatography [Code No: IPK0106]

This is a total lipid and mycolic acid composition analysis system.

Drug combination assay (Checker board) [Code No: IPK0107]

This is an in vitro combination assay based on resazurin (compusyn analysis).

Drug combination assay in ex vivo [Code No: IPK0108]

This is an in vitro combination assay based on QIM (compusyn analysis).

Bacteriolytic assay [Code No: IPK0109]

This assay measures the release of adenylate kinase from burst M. tuberculosis to screen bacteriolytic compounds.

Latent TB in vitro assay [Code No: IPK0110]

This assay utilizes M. tuberculosis mc2 strain, a penthothenate auxotroph, to induce non-replicative M. tuberculosis in broth culture medium.

Membrane MoA evaluation [Code No: IPK0111]

This assay measures membrane defects by compounds using M. tuberculosis and M. bovis strains that harbor an iniCAB promoter -lacZ fusion construct.