The Chemical & Structural Biology of Pathogens Laboratory at the Institut Pasteur Korea conducts research to develop various approaches to combat infectious diseases. Specifically, the lab focuses on discovering and developing small-molecule compounds to control a range of pathogens, including malaria and viruses. To achieve this, we utilize biochemical, biophysical, molecular biology, and cell biology techniques, such as analyzing the three-dimensional structures of proteins and performing high-content/high-throughput screening. In addition to identifying the mechanisms of action of the inhibitors we discover, the lab also conducts efficacy evaluations of the developed therapeutics using animal models.

Our capabilities/assets include:
• Qualitative analysis of inhibitor-protein binding and interactions using structural biology and molecular modeling
• Discovery and optimization of inhibitors through high-throughput screening based on target proteins
• Phenotype-based discovery of pathogen (e.g., malaria and other protozoa) inhibitors, mechanism of action studies, and efficacy evaluation using animal models