Research & Technology
Translational Research
Research & Technology
Research & Technology
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- Screening Discovery Platform
- Screening Discovery Platform combines automated robotics, advanced imaging microscopes, and infectious disease models with the high-throughput / high-content screening (HTS/HCS) platforms in the BSL-2 and -3 labs to probe the chemical and genomic landscape for "hits" that reverse disease-specific phenotypes. These large data sets are then interrogated with computational engines and informatic databases to identify the most promising candidates for drug development.
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- Medicinal Chemistry
- Medicinal Chemistry team seeks to efficiently optimize candidate drugs iteratively using chemical design and synthesis based upon: phenotypic/ target-based screening, structure-activity-relationship (SAR) and "ADMET" (absorption, distribution, metabolism, elimination, toxicity) analyses. Our work aims ultimately to improve candidate compounds by enhancing drug potency and "drug-like" properties. Our platform provides a "one-stop-shop" from drug design up to preclinical stage development.
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- Animal Research Lab
- The Animal Research Lab carries out research activities that utilize animal models to investigate and analyze complex phenomena and histopathology that occur during the development and treatment of disease at the systemic level. Specifically, it conducts new drug efficacy test in animal experiments for various diseases including infectious diseases in animal laboratories such as the specific pathogen free (SPF) zone and animal biosafety level-2, 3 (ABSL-2, ABSL-3) laboratories.
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- Technology Development Platform
- To maintain IPK’s cutting-edge phenotypic screening facility, we provide non-invasive imaging technologies in the cell, tissue, and small-animal models for quantitative phenotypic measurement enabling screening. Taking advantage of our multi-disciplinary team composed of molecular biologists, immunologists, and imaging specialists, we develop optical molecular probes and imaging technologies for studying disease in situ across macro- to microscopic spatial and temporal scales.
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- Lab Support
- Lab Support team provides various support for a broad set of experiments, designs and fabricates small equipment peripherals and accessories, assures significant equipment maintenance, and provides technical and administrative support to daily research activities of all internal research teams.