Institut Pasteur Korea
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- Screening Platform Lab.
- Screening Discovery Platform combines automated robotics, advanced imaging microscopes, and infectious disease models with the high-throughput / high-content screening (HTS/HCS) platforms in the BSL-2 and -3 labs to probe the chemical and genomic landscape for "hits" that reverse disease-specific phenotypes. These large data sets are then interrogated with computational engines and informatic databases to identify the most promising candidates for drug development.
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- Applied Molecular Biochemistry Lab.
- The Applied Molecular Biochemistry Laboratory (AMBL) integrates in the Core Technology Group, within the Platform Division of the Institute. AMBL is involved in fundamental as well as applied research projects, and combines molecular biology, biochemistry-biophysics, and cellular biology techniques to develop qualitative and quantitative target-based assays that are crucial for both diagnostics and therapeutics discovery.
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- AI Drug Discovery Lab.
- Medicinal Chemistry team seeks to efficiently optimize candidate drugs iteratively using chemical design and synthesis based upon: phenotypic/ target-based screening, structure-activity-relationship (SAR) and "ADMET" (absorption, distribution, metabolism, elimination, toxicity) analyses. Our work aims ultimately to improve candidate compounds by enhancing drug potency and "drug-like" properties. Our platform provides a "one-stop-shop" from drug design up to preclinical stage development.
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- Chemical & Structural Biology of Pathogen Lab.
- The Chemical & Structural Biology of Pathogens Laboratory focuses on the discovery of inhibitors targeting pathogen proteins by leveraging structural biology and drug screening techniques. Through collaboration with various teams within and outside the institute, the lab contributes to strengthening the global drug development pipeline by identifying and characterizing inhibitors for malaria, viruses, cancer, and other diseases.
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- Animal Research & Operation Lab.
- The Animal Research Lab carries out research activities that utilize animal models to investigate and analyze complex phenomena and histopathology that occur during the development and treatment of disease at the systemic level. Specifically, it conducts new drug efficacy test in animal experiments for various diseases including infectious diseases in animal laboratories such as the specific pathogen free (SPF) zone and animal biosafety level-2, 3 (ABSL-2, ABSL-3) laboratories.